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PDBsum entry 8ejs
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Protein binding
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PDB id
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8ejs
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PDB id:
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| Name: |
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Protein binding
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Title:
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Kelch domain of human keap1 bound to nrf2 linear peptide, ac-(bala) dpetge-nh2
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Structure:
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Kelch-like ech-associated protein 1. Chain: a, b. Fragment: unp residues 320-812. Synonym: cytosolic inhibitor of nrf2,inrf2,kelch-like protein 19. Engineered: yes. Peptide from nuclear factor erythroid 2-related factor 2. Chain: c. Synonym: nf-e2-related factor 2,nfe2-related factor 2,nrf-2,hebp1, nuclear factor,erythroid derived 2,like 2.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: keap1, inrf2, kiaa0132, klhl19. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
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Resolution:
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2.82Å
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R-factor:
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0.219
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R-free:
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0.266
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Authors:
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S.N.Muellers,K.N.Allen
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Key ref:
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S.N.Muellers
et al.
The benefit of cyclization: a comparison of cyclic an linear peptide inhibitors of the keap1/nrf2 protein-P interaction.
To be published,
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Date:
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18-Sep-22
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Release date:
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27-Sep-23
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PROCHECK
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Headers
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References
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Q14145
(KEAP1_HUMAN) -
Kelch-like ECH-associated protein 1 from Homo sapiens
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Seq:
Struc:
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624 a.a.
283 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Links
