PDBsum entry 8dwc

Signaling protein

PDB id: 8dwc

Contents

Protein chains

11 a.a.

338 a.a.

51 a.a.

250 a.a.

231 a.a.

221 a.a.

PDB id:

8dwc

Name:

Signaling protein

Title:

Cryoem structure of gq-coupled mrgprx1 with peptide agonist bam8-22

Structure:

Proenkephalin-a. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Bos taurus. Cattle. Organism_taxid: 9913. Gene: penk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Authors:

Y.Liu,C.Cao,J.F.Fay,B.L.Roth

Key ref:

Y.Liu et al. (2023). Ligand recognition and allosteric modulation of the h mrgprx1 receptor.. Nat chem biol, 19, 416. PubMed id: 36302898

Date:

01-Aug-22 Release date: 02-Nov-22

Protein chain

P01211  (PENK_BOVIN) -  Proenkephalin-A from Bos taurus

Seq: 263 a.a.

Struc: 11 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

Q96LB2  (MRGX1_HUMAN) -  Mas-related G-protein coupled receptor member X1 from Homo sapiens

Seq: 322 a.a.

Struc: 250 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

No UniProt id for this chain

Struc: 221 a.a.