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PDBsum entry 8df5
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protein ligands metals Protein-protein interface(s) links
Viral protein/hydrolase/immune system PDB id
8df5

 

 

 

 

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Contents
Protein chains
224 a.a.
214 a.a.
587 a.a.
217 a.a.
215 a.a.
200 a.a.
Ligands
NAG-NAG ×2
EDO ×30
NAG ×13
Metals
_CL ×22
_ZN ×2
Waters ×1017
PDB id:
8df5
Name: Viral protein/hydrolase/immune system
Title: Sars-cov-2 beta rbd in complex with human ace2 and s304 fab and s309 fab
Structure: S309 fab heavy chain. Chain: a, c. Engineered: yes. S309 fab light chain. Chain: b, d. Engineered: yes. Angiotensin-converting enzyme 2. Chain: e, f. Synonym: angiotensin-converting enzyme homolog,aceh,angiotensin-
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Human. Gene: ace2, unq868/pro1885. Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049.
Resolution:
2.70Å     R-factor:   0.179     R-free:   0.217
Authors: M.Mccallum,Seattle Structural Genomics Center For Infectious Disease (Ssgcid),G.Snell,D.Veesler
Key ref: T.N.Starr et al. (2022). Shifting mutational constraints in the sars-Cov-2 receptor-Binding domain during viral evolution.. Science, 377, 420. PubMed id: 35762884
Date:
21-Jun-22     Release date:   03-Aug-22    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
No UniProt id for this chain
Struc: 224 a.a.
Protein chains
No UniProt id for this chain
Struc: 214 a.a.
Protein chains
Q9BYF1  (ACE2_HUMAN) -  Angiotensin-converting enzyme 2 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		805 a.a.
587 a.a.
Protein chains
No UniProt id for this chain
Struc: 217 a.a.
Protein chains
No UniProt id for this chain
Struc: 215 a.a.
Protein chains
P0DTC2  (SPIKE_SARS2) -  Spike glycoprotein from Severe acute respiratory syndrome coronavirus 2
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1273 a.a.
200 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 1: Chains E, F: E.C.3.4.17.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 2: Chains E, F: E.C.3.4.17.23  - angiotensin-converting enzyme 2.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: angiotensin II + H2O = angiotensin-1-7 + L-phenylalanine
angiotensin II
 + H2O
 = angiotensin-(1-7)
 + L-phenylalanine
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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