PDBsum entry 8d3f

Transcription

PDB id: 8d3f

Contents

Protein chain

572 a.a.

PDB id:

8d3f

Name:

Transcription

Title:

Crystal structure of human stat1 in complex with the repeat region from toxoplasma protein tgist

Structure:

Signal transducer and activator of transcription 1- alpha/beta,inhibitor of stat1-dependent transcription tgist. Chain: a. Fragment: stat1-binding region. Synonym: transcription factor isgf-3 components p91/p84. Engineered: yes

Source:

Homo sapiens, toxoplasma gondii gt1. Human. Organism_taxid: 9606, 507601. Gene: stat1, tgrh88_087790. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.97Å R-factor: 0.250 R-free: 0.288

Authors:

Z.Huang,H.Liu,J.C.Nix,G.K.Amarasinghe,L.D.Sibley

Key ref:

Z.Huang et al. Crystal structure of human stat1 in complex with stat1-Binding region from toxoplasma protein tgist. To be published, . PubMed id: 35831295

Date:

01-Jun-22 Release date: 06-Jul-22

Protein chain

A0A7J6KA90  (A0A7J6KA90_TOXGO) -  Inhibitor of STAT1-dependent transcription TgIST from Toxoplasma gondii

Seq: 890 a.a.

Struc: 572 a.a.*

Protein chain

P42224  (STAT1_HUMAN) -  Signal transducer and activator of transcription 1-alpha/beta from Homo sapiens

Seq: 750 a.a.

Struc: 572 a.a.*

* PDB and UniProt seqs differ at 382 residue positions (black crosses)