PDBsum entry 8ctf

Viral protein,hydrolase/inhibitor

PDB id: 8ctf

Contents

Protein chain

179 a.a.

Ligands

ACT

Q3O

Metals

_MN ×2

Waters ×53

PDB id:

8ctf

Name:

Viral protein,hydrolase/inhibitor

Title:

The n-terminal domain of pa endonuclease from the influenza h1n1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2- carboxylic acid

Structure:

Polymerase acidic protein. Chain: a. Synonym: RNA-directed RNA polymerase subunit p2. Engineered: yes

Source:

Influenza a virus. Organism_taxid: 641501. Strain: swl a/california/04/2009 h1n1. Gene: pa. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Resolution:

2.14Å R-factor: 0.207 R-free: 0.243

Authors:

A.J.Kohlbrand,R.W.Stokes,J.Karges,H.Seo,B.Sankaran,S.M.Cohen

Key ref:

R.W.Stokes et al. (2023). Carboxylic acid isostere derivatives of hydroxypyridi as core scaffolds for influenza endonuclease inhibito. Acs med chem lett, 14, 75. PubMed id: 36655124

Date:

14-May-22 Release date: 21-Dec-22

Protein chain

C3W5S0  (C3W5S0_I09A0) -  Polymerase acidic protein from Influenza A virus (strain swl A/California/04/2009 H1N1)

Seq: 716 a.a.

Struc: 179 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.-.-