PDBsum entry 8cli

Transcription

PDB id: 8cli

Contents

Protein chains

542 a.a.

689 a.a.

579 a.a.

DNA/RNA

Metals

_ZN ×2

PDB id:

8cli

Name:

Transcription

Title:

Tfiiic taub-DNA monomer

Structure:

General transcription factor 3c polypeptide 1. Chain: a. Synonym: tf3c-alpha,tfiiic box b-binding subunit,transcription factor iiic 220 kda subunit,tfiiic 220 kda subunit,tfiiic220,transcription factor iiic subunit alpha. Engineered: yes. General transcription factor 3c polypeptide 4. Chain: b. Synonym: tf3c-delta,transcription factor iiic 90 kda subunit,tfiiic

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gtf3c1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gtf3c4. Gene: gtf3c2, kiaa0011. Synthetic: yes.

Authors:

W.Seifert-Davila,M.Girbig,L.Hauptmann,T.Hoffmann,S.Eustermann, C.W.Mueller

Key ref:

S.D.Wolfram et al. Cryo-Em structures of human tfiiic reveal a multi-Ste mechanism for tRNA gene promoter recognition. Adv sci, . PubMed id: 37418517

Date:

16-Feb-23 Release date: 21-Jun-23

Protein chain

Q12789  (TF3C1_HUMAN) -  General transcription factor 3C polypeptide 1 from Homo sapiens

Seq: 2109 a.a.

Struc: 542 a.a.

Protein chain

Q9UKN8  (TF3C4_HUMAN) -  General transcription factor 3C polypeptide 4 from Homo sapiens

Seq: 822 a.a.

Struc: 689 a.a.

Protein chain

Q8WUA4  (TF3C2_HUMAN) -  General transcription factor 3C polypeptide 2 from Homo sapiens

Seq: 911 a.a.

Struc: 579 a.a.

DNA/RNA chains

A-A-A-G-G-T-T-G-T-G-G-G-T-T-C-G-A-G-T-C-C-C-A-C-C-A-G-A-G-T-C-G-C-T-T 35 bases

A-A-G-C-G-A-C-T-C-T-G-G-T-G-G-G-A-C-T-C-G-A-A-C-C-C-A-C-A-A-C-C-T-T-T 35 bases

Enzyme reactions

• Enzyme class: Chain B: E.C.2.3.1.48 - histone acetyltransferase.
• Reaction: L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site