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PDBsum entry 8cbh
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Signaling protein
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PDB id
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8cbh
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PDB id:
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| Name: |
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Signaling protein
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Title:
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Shp2 in complex with a novel allosteric inhibitor
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Structure:
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Tyrosine-protein phosphatase non-receptor type 11. Chain: a, b. Synonym: protein-tyrosine phosphatase 1d,ptp-1d,protein-tyrosine phosphatase 2c,ptp-2c,sh-ptp2,shp-2,shp2,sh-ptp3. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn11, ptp2c, shptp2. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.24Å
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R-factor:
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0.217
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R-free:
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0.264
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Authors:
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R.Di Fabio,A.Petrocchi
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Key ref:
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E.Torrente
et al.
(2023).
Discovery of a novel series of imidazopyrazine deriva as potent shp2 allosteric inhibitors..
Acs med chem lett,
14,
156.
PubMed id:
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Date:
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25-Jan-23
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Release date:
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26-Apr-23
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PROCHECK
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Headers
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References
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Q06124
(PTN11_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 11 from Homo sapiens
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Seq:
Struc:
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593 a.a.
485 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
