PDBsum entry 8c8s

Hydrolase

PDB id: 8c8s

Contents

Protein chain

341 a.a.

Ligands

U2O

Metals

_ZN ×2

Waters ×101

PDB id:

8c8s

Name:

Hydrolase

Title:

Crystal structure of human DNA cross-link repair 1a in complex with hydroxamic acid inhibitor (compound 21).

Structure:

DNA cross-link repair 1a protein. Chain: a. Synonym: beta-lactamase dclre1a,snm1 homolog a,hsnm1,hsnm1a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dclre1a, kiaa0086, snm1, snm1a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.80Å R-factor: 0.214 R-free: 0.246

Authors:

Y.Yosaatmadja,J.A.Newman,H.T.Baddock,M.Bielinski,F.Von Delft, C.Bountra,P.J.Mchugh,C.J.Schofield,O.Gileadi

Key ref:

Y.Yosaatmadja et al. Crystal structure of human DNA cross-Link repair 1a i complex with hydroxamic acid inhibitor (compound 21).. To be published, . PubMed id: 38817593

Date:

20-Jan-23 Release date: 31-Jan-24

Protein chain

Q6PJP8  (DCR1A_HUMAN) -  DNA cross-link repair 1A protein from Homo sapiens

Seq: 1040 a.a.

Struc: 341 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)