PDBsum entry 8bpy

Hydrolase

PDB id: 8bpy

Contents

Protein chains

315 a.a.

Ligands

R4I

Metals

_NA ×2

_ZN ×2

_MG ×2

PDB id:

8bpy

Name:

Hydrolase

Title:

X-ray structure of pde9a in complex with inhibitor 13a

Structure:

High affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9a. Chain: a, b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

3.30Å R-factor: 0.250 R-free: 0.312

Authors:

H.Steuber

Key ref:

D.Meibom et al. (2022). Bay-7081: a potent, Selective, And orally bioavailabl cyanopyridone-Based pde9a inhibitor.. J med chem, 65, 16420. PubMed id: 36475653

Date:

18-Nov-22 Release date: 28-Dec-22

Protein chains

O76083  (PDE9A_HUMAN) -  High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A from Homo sapiens

Seq: 593 a.a.

Struc: 315 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase.
• Reaction: 3',5'-cyclic GMP + H2O = GMP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site