PDBsum entry 8b9h

Transferase

PDB id: 8b9h

Contents

Protein chain

274 a.a.

Ligands

Q7F

GOL ×4

Waters ×177

PDB id:

8b9h

Name:

Transferase

Title:

Crystal structure of jak2 jh2 in complex with z902-a3

Structure:

Tyrosine-protein kinase jak2. Chain: a. Synonym: janus kinase 2,jak-2. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.50Å R-factor: 0.182 R-free: 0.209

Authors:

T.Haikarainen,O.Silvennoinen

Key ref:

A.T.Virtanen et al. (2023). Identification of novel small molecule ligands for ja pseudokinase domain.. Pharmaceuticals, 16, . PubMed id: 36678572

Date:

06-Oct-22 Release date: 01-Feb-23

Protein chain

O60674  (JAK2_HUMAN) -  Tyrosine-protein kinase JAK2 from Homo sapiens

Seq: 1132 a.a.

Struc: 274 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = Q7F) matches with 41.67% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site