PDBsum entry 8b5c

Peptide binding protein

PDB id: 8b5c

Contents

Protein chains

127 a.a.

11 a.a.

Waters ×78

PDB id:

8b5c

Name:

Peptide binding protein

Title:

Human brd4 bromdomain 1 in complex with a h4 peptide containing apmtri (h4k5/8apmtri)

Structure:

Bromodomain-containing protein 4. Chain: a. Synonym: protein hunk1. Engineered: yes. H4k5/8apmtri. Chain: b. Engineered: yes. Other_details: non-natural amino acid apmtri containing h4 peptide

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.58Å R-factor: 0.186 R-free: 0.208

Authors:

M.B.Braun,N.Bartlick,T.Stehle

Key ref:

S.Kirchgassner et al. Synthesis, Biochemical characterization, And genetic encoding of a 1,2,4-Triazole amino acid as an acetyll mimic for bromodomains of the bet family.. Angew chem int ed engl, . PubMed id: 36585954

Date:

22-Sep-22 Release date: 11-Jan-23

Protein chain

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 127 a.a.*

Protein chain

P62805  (H4_HUMAN) -  Histone H4 from Homo sapiens

Seq: 103 a.a.

Struc: 10 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)