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PDBsum entry 8aoc
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Signaling protein
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PDB id
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8aoc
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PDB id:
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| Name: |
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Signaling protein
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Title:
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Specific covalent inhibitor of erk2
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Structure:
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Mitogen-activated protein kinase 1. Chain: a. Synonym: map kinase 1,mapk 1,ert1,extracellular signal-regulated kinase 2,erk-2,map kinase isoform p42,p42-mapk,mitogen-activated protein kinase 2,map kinase 2,mapk 2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk1, erk2, prkm1, prkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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1.62Å
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R-factor:
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0.180
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R-free:
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0.217
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Authors:
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A.Cleasby
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Key ref:
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J.D.St denis
et al.
X-Ray screening of an electrophilic fragment library application toward the development of a novel erk 1/2 covalent inhibitor..
J med chem,
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PubMed id:
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Date:
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08-Aug-22
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Release date:
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28-Sep-22
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PROCHECK
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Headers
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References
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P28482
(MK01_HUMAN) -
Mitogen-activated protein kinase 1 from Homo sapiens
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Seq:
Struc:
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360 a.a.
346 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.11.24
- mitogen-activated protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
