PDBsum entry 8a9c

Transferase

PDB id: 8a9c

Contents

Protein chains

527 a.a.

Ligands

TPP

Metals

_MG

Waters ×786

PDB id:

8a9c

Name:

Transferase

Title:

Structure of truncated 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from klebsiella pneumoniae in complex with cofactor tpp

Structure:

1-deoxy-d-xylulose-5-phosphate synthase. Chain: a, b. Synonym: 1-deoxyxylulose-5-phosphate synthase,dxp synthase,dxps. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: dxs_3, dxs, dxs_1, bn49_1346, fxn67_12755, gjj18_13560, gjj26_020415, nctc11679_04435, nctc13465_06397, nctc3279_00555, nctc5047_01280, nctc5052_00313, nctc9140_02292, nctc9645_03343, nctc9661_05006, samea3649733_02709, samea4364603_02966, dxs_3, dxs, dxs_1, dxs_2, bn49_1346, drb11_07540, fxn67_12755, nctc11679_04435, nctc13465_06397, nctc3279_00555, nctc5047_01280, nctc5052_00313, nctc9140_02292, nctc9645_03343, nctc9661_05006, samea3512100_02923,

Resolution:

1.80Å R-factor: 0.156 R-free: 0.191

Authors:

S.Adam,A.Hirsch

Key ref:

S.Adam and a.hirsch Structure of truncated 1-Deoxy-D-Xylulose 5-Phosphate synthase (dxs) from klebsiella pneumoniae in complex cofactor tpp. To be published, .

Date:

28-Jun-22 Release date: 12-Jul-23

Protein chains

A6T5F3  (DXS_KLEP7) -  1-deoxy-D-xylulose-5-phosphate synthase from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

Seq: 620 a.a.

Struc: 527 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase.
• Pathway: Non-Mevalonate Terpenoid biosynthesis
• Reaction: D-glyceraldehyde 3-phosphate + pyruvate + H⁺ = 1-deoxy-D-xylulose 5-phosphate + CO2
• Cofactor: Thiamine diphosphate

Thiamine diphosphate (Bound ligand (Het Group name = TPP) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site