PDBsum entry 8a7c

Biosynthetic protein

PDB id: 8a7c

Contents

Protein chains

345 a.a.

Ligands

GOL ×2

IPE ×2

ZOL ×2

Metals

_MG ×6

Waters ×731

PDB id:

8a7c

Name:

Biosynthetic protein

Title:

Pcids1 in complex with mg2+, ipp, and zol

Structure:

Isoprenyl diphosphate synthase. Chain: a, b. Engineered: yes

Source:

Phaedon cochleariae. Mustard beetle. Organism_taxid: 80249. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.20Å R-factor: 0.130 R-free: 0.154

Authors:

F.Ecker,W.Boland,M.Groll

Key ref:

F.Ecker et al. Metal-Dependent enzyme symmetry guides the biosynthet of terpene precursors. To be published, . PubMed id: 37308711

Date:

20-Jun-22 Release date: 31-May-23

Protein chains

M1JS91  (M1JS91_PHACE) -  Farnesyl pyrophosphate synthase from Phaedon cochleariae

Seq: 429 a.a.

Struc: 345 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.5.1.1 - dimethylallyltranstransferase.
• Pathway: Terpenoid biosynthesis
• Reaction: isopentenyl diphosphate + dimethylallyl diphosphate = (2E)- geranyl diphosphate + diphosphate

isopentenyl diphosphate (Bound ligand (Het Group name = IPE) corresponds exactly) + dimethylallyl diphosphate = (2E)- geranyl diphosphate + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site