PDBsum entry 8a1f

Cell adhesion

PDB id: 8a1f

Contents

Protein chains

353 a.a.

Ligands

NAG-NAG-FUC

NAG-NAG-BMA-MAN

NAG-NAG

NAG-NAG-BMA

NAG ×2

Metals

_NA ×2

Waters ×2

PDB id:

8a1f

Name:

Cell adhesion

Title:

Human ptprk n-terminal domains mam-ig-fn1

Structure:

Receptor-type tyrosine-protein phosphatase kappa. Chain: a, b. Synonym: protein-tyrosine phosphatase kappa,r-ptp-kappa. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptprk, ptpk. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293-f

Resolution:

3.00Å R-factor: 0.230 R-free: 0.274

Authors:

I.M.Hay,S.C.Graham,H.J.Sharpe,J.E.Deane

Key ref:

I.M.Hay et al. (2023). Determinants of receptor tyrosine phosphatase homophi adhesion: structural comparison of ptprk and ptprm extracellular domains.. J biol chem, 299, 02750. PubMed id: 36436563

Date:

01-Jun-22 Release date: 15-Mar-23

Protein chains

Q15262  (PTPRK_HUMAN) -  Receptor-type tyrosine-protein phosphatase kappa from Homo sapiens

Seq: 1439 a.a.

Struc: 353 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site