PDBsum entry 7zzh

Transferase

PDB id: 7zzh

Contents

Protein chain

264 a.a.

Ligands

CIT

KIO

Waters ×59

PDB id:

7zzh

Name:

Transferase

Title:

Crystal structure of NAD kinase 1 from listeria monocytogenes in complex with a linear di-adenosine derivative

Structure:

NAD kinase 1. Chain: a. Synonym: atp-dependent NAD kinase. Engineered: yes

Source:

Listeria monocytogenes egd-e. Organism_taxid: 169963. Gene: nadk1, lmo0968. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.00Å R-factor: 0.200 R-free: 0.232

Authors:

M.Gelin,G.Labesse

Key ref:

D.A.Clement et al. (2023). Synthesis and structure-Activity relationship studies original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria.. Eur j med chem, 246, 14941. PubMed id: 36455355

Date:

25-May-22 Release date: 11-Jan-23

Protein chain

Q8Y8D7  (NADK1_LISMO) -  NAD kinase 1 from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

Seq: 264 a.a.

Struc: 264 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.1.23 - NAD(+) kinase.
• Reaction: NAD⁺ + ATP = ADP + NADP⁺ + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site