PDBsum entry 7zym

Transferase

PDB id: 7zym

Contents

Protein chain

321 a.a.

Ligands

6GY

Waters ×22

PDB id:

7zym

Name:

Transferase

Title:

Crystal structure of egfr-t790m/c797s in complex with brigatinib

Structure:

Epidermal growth factor receptor. Chain: a. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.50Å R-factor: 0.194 R-free: 0.224

Authors:

J.Niggenaber,S.Kleinboelting,M.P.Mueller,D.Rauh

Key ref:

T.Grabe et al. Addressing the osimertinib resistance mutation egfr-L858r/c797s with reversible aminopyrimidines. Acs med chem lett, . PubMed id: 37197473

Date:

25-May-22 Release date: 03-May-23

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 321 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site