PDBsum entry 7zrt

Hydrolase

PDB id: 7zrt

Contents

Protein chains

247 a.a.

17 a.a.

Ligands

SO4 ×2

PEG ×2

EDO ×3

1PE

ZBR

Waters ×119

PDB id:

7zrt

Name:

Hydrolase

Title:

Crystal structure of human urokinase-type plasminogen activator in complex with bicycle peptide inhibitor uk970

Structure:

Urokinase-type plasminogen activator. Chain: a. Synonym: upa. Engineered: yes. Synthetic peptide uk970. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney 293. Synthetic: yes. Synthetic construct.

Resolution:

1.80Å R-factor: 0.209 R-free: 0.229

Authors:

A.Caregnato,P.Angela,Y.Mazzoccato,N.Frasson,A.Angelini,L.Cendron

Key ref:

A.Caregnato et al. Crystal structure of human urokinase-Type plasminogen activator in complex with bicycle peptide inhibitor u. To be published, .

Date:

05-May-22 Release date: 15-Nov-23

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 247 a.a.*

Protein chain

No UniProt id for this chain

Struc: 17 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.