PDBsum entry 7zpc

Cell cycle

PDB id: 7zpc

Contents

Protein chain

291 a.a.

Ligands

JLC

Waters ×277

PDB id:

7zpc

Name:

Cell cycle

Title:

Cdk2 in complex 9k-dos

Structure:

Cyclin-dependent kinase 2. Chain: a. Synonym: cell division protein kinase 2,p33 protein kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.40Å R-factor: 0.201 R-free: 0.221

Authors:

J.E.Watt,M.P.Martin,M.E.N.Noble

Key ref:

M.Uguen et al. (2022). Build-Couple-Transform: a paradigm for lead-Like libr synthesis with scaffold diversity.. J med chem, 65, 11322. PubMed id: 35943172

Date:

27-Apr-22 Release date: 01-Feb-23

Protein chain

P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2 from Homo sapiens

Seq: 298 a.a.

Struc: 291 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.22 - cyclin-dependent kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site