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PDBsum entry 7zjp
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Transcription
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PDB id
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7zjp
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PDB id:
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| Name: |
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Transcription
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Title:
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Optimization of tead p-site binding fragment hit into in vivo active lead msc-4106
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Structure:
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Transcriptional enhancer factor tef-1. Chain: a, b. Synonym: ntef-1,protein gt-iic,tea domain family member 1,tead-1, transcription factor 13,tcf-13. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: tead1, tcf13, tef1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
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Resolution:
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2.19Å
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R-factor:
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0.193
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R-free:
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0.236
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Authors:
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F.Freire,T.Heinrich,C.Petersson,R.Schneider,S.Garg,D.Schwarz, J.Gunera,A.Seshire,L.Koetzner,S.Schlesiger,D.Musil,H.Schilke, B.Doerfel,P.Diehl,P.Boepple,A.R.Lemos,P.M.F.Sousa,F.Freire, T.M.Bandeiras,E.Carswell,N.Pearson,S.Sirohi,M.Hooker,E.Trivier, R.Broome,A.Balsiger,A.Crowden,C.Dillon,D.Wienke
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Key ref:
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T.Heinrich
et al.
Optimization of tead p-Site binding fragment hit into vivo active lead msc-4106..
J med chem,
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PubMed id:
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Date:
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11-Apr-22
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Release date:
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13-Jul-22
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PROCHECK
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Headers
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References
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P28347
(TEAD1_HUMAN) -
Transcriptional enhancer factor TEF-1 from Homo sapiens
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Seq:
Struc:
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426 a.a.
215 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Links
