PDBsum entry 7zg3

DNA binding protein

PDB id: 7zg3

Contents

Protein chains

305 a.a.

Ligands

IUX ×3

Metals

_NI

Waters ×154

PDB id:

7zg3

Name:

DNA binding protein

Title:

Structure of the mouse 8-oxoguanine DNA glycosylase mogg1 in complex with ligand th011228

Structure:

N-glycosylase/DNA lyase. Chain: a, b, c. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.30Å R-factor: 0.277 R-free: 0.307

Authors:

J.R.Davies,E.Scaletti,P.Stenmark

Key ref:

J.R.Davies et al. Structure of the mouse 8-Oxoguanine DNA glycosylase m complex with ligand th011228. To be published, .

Date:

01-Apr-22 Release date: 16-Aug-23

Protein chains

O08760  (OGG1_MOUSE) -  N-glycosylase/DNA lyase from Mus musculus

Seq: 345 a.a.

Struc: 305 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 1: E.C.3.2.2.- - ?????
• Enzyme class 2: E.C.4.2.99.18 - DNA-(apurinic or apyrimidinic site) lyase.
• Reaction: 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)- 2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho- 2'-deoxyribonucleoside-DNA + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.