PDBsum entry 7zef

Transcription

PDB id: 7zef

Contents

Protein chain

129 a.a.

Ligands

UUG

GOL

Waters ×129

PDB id:

7zef

Name:

Transcription

Title:

Brd4 in complex with fraglite22

Structure:

Bromodomain-containing protein 4. Chain: a. Synonym: protein hunk1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.12Å R-factor: 0.208 R-free: 0.233

Authors:

S.Turberville,M.P.Martin,I.Hope,M.E.M.Noble

Key ref:

G.Davison et al. (2022). Mapping ligand interactions of bromodomains brd4 and with fraglites and peplites─. J med chem, 65, 15416. PubMed id: 36367089

Date:

31-Mar-22 Release date: 23-Nov-22

Protein chain

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 129 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.?