PDBsum entry 7ykc

Biosynthetic protein

PDB id: 7ykc

Contents

Protein chains

370 a.a.

PDB id:

7ykc

Name:

Biosynthetic protein

Title:

Crystal structure of the phenylalanine-regulated 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase (aro3) from saccharomyces cerevisiae

Structure:

3-deoxy-d-arabino-heptulosonate-7-phosphate synthase. Chain: a, b. Synonym: 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase,dahp synthase,phospho-2-keto-3-deoxyheptonate aldolase. Engineered: yes

Source:

Saccharomyces cerevisiae s288c. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: aro3, ydr035w, yd9673.07. Expressed in: escherichia coli b. Expression_system_taxid: 37762

Resolution:

3.30Å R-factor: 0.256 R-free: 0.295

Authors:

H.Liu,Y.Luo

Key ref:

H.Liu et al. (2023). Mechanistic investigation of a d to n mutation in dah synthase that dictates carbon flux into the shikimate pathway in yeast.. Commun chem, 6, 152. PubMed id: 37454208

Date:

22-Jul-22 Release date: 26-Jul-23

Protein chains

P14843  (AROF_YEAST) -  Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 370 a.a.

Struc: 370 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase.
• Pathway: Shikimate and Chorismate Biosynthesis
• Reaction: D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2- dehydro-3-deoxy-D-arabino-heptonate + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site