PDBsum entry 7y9c

Transferase

PDB id: 7y9c

Contents

Protein chains

274 a.a.

12 a.a.

Ligands

SAH ×2

Waters ×394

PDB id:

7y9c

Name:

Transferase

Title:

Crystal structure of mettl9 in complex with slc39a5 peptide and sah

Structure:

Protein-l-histidine n-pros-methyltransferase. Chain: a, b. Synonym: dora reverse strand protein,drev,drev1,methyltransferase- like protein 9,hmettl9, mettl9. Engineered: yes. Mutation: yes. Slc39a5. Chain: c, d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mettl9, drev, cgi-81. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Expressed in: synthetic construct.

Resolution:

2.10Å R-factor: 0.195 R-free: 0.243

Authors:

H.Xie,X.Wang,C.Xu

Key ref:

X.Wang et al. (2023). Molecular basis for mettl9-Mediated n1-Histidine meth. Cell discov, 9, 38. PubMed id: 37015930

Date:

24-Jun-22 Release date: 12-Apr-23

Protein chains

Q9H1A3  (METL9_HUMAN) -  Protein-L-histidine N-pros-methyltransferase from Homo sapiens

Seq: 318 a.a.

Struc: 274 a.a.*

Protein chains

Q6ZMH5  (S39A5_HUMAN) -  Zinc transporter ZIP5 from Homo sapiens

Seq: 540 a.a.

Struc: 12 a.a.*

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class 2: Chains A, B: E.C.2.1.1.- - ?????
• Enzyme class 3: Chains C, D: E.C.?

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.