PDBsum entry 7y1h

Translation/inhibitor

PDB id: 7y1h

Contents

Protein chains

487 a.a.

Ligands

F99 ×2

ATP ×2

Metals

_MG ×4

_ZN ×2

Waters ×201

PDB id:

7y1h

Name:

Translation/inhibitor

Title:

Controlling fibrosis using compound with novel binding mode to prolyl- tRNA synthetase 1

Structure:

Bifunctional glutamate/proline--tRNA ligase. Chain: a, b. Synonym: bifunctional aminoacyl-tRNA synthetase,cell proliferation- inducing gene 32 protein,glutamatyl-prolyl-tRNA synthetase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs1, eprs, glns, pars, qars, qprs, pig32. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.99Å R-factor: 0.208 R-free: 0.243

Authors:

S.Kim,I.Yoon,J.Son,S.Park,K.Y.Hwang

Key ref:

S.Kim et al. Controlling fibrosis using compound with novel bindin to prolyl-Trna synthetase 1. To be published, . PubMed id: 37212275

Date:

08-Jun-22 Release date: 05-Jul-23

Protein chains

P07814  (SYEP_HUMAN) -  Bifunctional glutamate/proline--tRNA ligase from Homo sapiens

Seq: 1512 a.a.

Struc: 487 a.a.

Enzyme reactions

• Enzyme class 1: E.C.6.1.1.15 - proline--tRNA ligase.
• Reaction: tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate

tRNA(Pro) (Bound ligand (Het Group name = ATP) corresponds exactly) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate

• Enzyme class 2: E.C.6.1.1.17 - glutamate--tRNA ligase.
• Reaction: tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate

tRNA(Glu) (Bound ligand (Het Group name = ATP) corresponds exactly) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site