PDBsum entry 7xn4

Toxin

PDB id: 7xn4

Contents

Protein chains

210 a.a.

422 a.a.

169 a.a.

58 a.a.

Ligands

NAD

PDB id:

7xn4

Name:

Toxin

Title:

Cryo-em structure of copc-cam-caspase-3 with NAD+

Structure:

Caspase-3. Chain: a, c. Synonym: casp-3,apopain,cysteine protease cpp32,cpp-32,protein yama, srebp cleavage activity 1,sca-1. Engineered: yes. Arginine adp-riboxanase copc. Chain: b. Engineered: yes. Calmodulin-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: casp3, cpp32. Expressed in: bacteria latreille et al. 1825. Expression_system_taxid: 629395. Chromobacterium violaceum. Organism_taxid: 536. Strain: atcc 12472 / dsm 30191 / jcm 1249 / nbrc 12614 / ncimb 9131

Authors:

K.Zhang,T.Peng,X.Y.Tao,M.Tian,Y.X.Li,Z.Wang,S.F.Ma,S.F.Hu,X.Pan, J.Xue,J.W.Luo,Q.L.Wu,Y.Fu,S.Li

Key ref:

K.Zhang et al. (2022). Structural insights into caspase adpr deacylization catalyzed by a bacterial effector and host calmodulin. Mol cell, 82, 4712. PubMed id: 36423631

Date:

28-Apr-22 Release date: 14-Dec-22

Protein chain

P42574  (CASP3_HUMAN) -  Caspase-3 from Homo sapiens

Seq: 277 a.a.

Struc: 210 a.a.

Protein chain

Q7NWF2  (Q7NWF2_CHRVO) -  Arginine ADP-riboxanase CopC from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / CCUG 213 / NBRC 12614 / NCIMB 9131 / NCTC 9757 / MK)

Seq: 487 a.a.

Struc: 422 a.a.

Protein chain

P42574  (CASP3_HUMAN) -  Caspase-3 from Homo sapiens

Seq: 277 a.a.

Struc: 169 a.a.

Protein chain

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 58 a.a.

Enzyme reactions

• Enzyme class 2: Chains A, C: E.C.3.4.22.56 - caspase-3.
• Enzyme class 3: Chain B: E.C.4.3.99.- - ?????

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.