PDBsum entry 7x9c

Signaling protein

PDB id: 7x9c

Contents

Protein chains

302 a.a.

217 a.a.

336 a.a.

54 a.a.

36 a.a.

PDB id:

7x9c

Name:

Signaling protein

Title:

Cryo-em structure of neuropeptide y y4 receptor in complex with pp and gi

Structure:

Neuropeptide y receptor type 4. Chain: r. Synonym: npy4-r,pancreatic polypeptide receptor 1,pp1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: npy4r, ppyr1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnai1. Gene: gnb1. Gene: gng2.

Authors:

T.Tang,S.Han,Q.Zhao,B.Wu

Key ref:

T.Tang et al. (2022). Receptor-Specific recognition of npy peptides reveale structures of npy receptors.. Sci adv, 8, m1232. PubMed id: 35507650

Date:

15-Mar-22 Release date: 18-May-22

Protein chain

P50391  (NPY4R_HUMAN) -  Neuropeptide Y receptor type 4 from Homo sapiens

Seq: 375 a.a.

Struc: 302 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

P01298  (PAHO_HUMAN) -  Pancreatic polypeptide prohormone from Homo sapiens

Seq: 95 a.a.

Struc: 36 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains R, A, B, C, P: E.C.?