PDBsum entry 7wzc

Cell invasion

PDB id: 7wzc

Contents

Protein chain

184 a.a.

Ligands

GOL

GDP

Metals

_MG

Waters ×117

PDB id:

7wzc

Name:

Cell invasion

Title:

An open conformation form2 of switch ii for rhoa gdp-bound state

Structure:

Transforming protein rhoa. Chain: a. Fragment: c16v,c20s,c83v,c159t. Synonym: rho cdna clone 12,h12. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rhoa, arh12, arha, rho12. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.80Å R-factor: 0.208 R-free: 0.264

Authors:

H.Jiang,C.Luo

Key ref:

H.Jiang and c.luo An open conformation form2 of switch ii for rhoa. To be published, . PubMed id: 36781028

Date:

17-Feb-22 Release date: 22-Feb-23

Protein chain

P61586  (RHOA_HUMAN) -  Transforming protein RhoA from Homo sapiens

Seq: 193 a.a.

Struc: 184 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.6.5.2 - small monomeric GTPase.
• Reaction: GTP + H2O = GDP + phosphate + H⁺

GTP + H2O = GDP (Bound ligand (Het Group name = GDP) corresponds exactly) + phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site