PDBsum entry 7wt4

Immune system

PDB id: 7wt4

Contents

Protein chains

277 a.a.

100 a.a.

233 a.a.

89 a.a.

Ligands

ARG-TYR-GLY-PHE-VAL-ALA-ASN-PHE ×2

EDO ×46

TRS ×2

ACT

Metals

_ZN ×3

Waters ×426

PDB id:

7wt4

Name:

Immune system

Title:

Crystal structure of hla-a 2402 Complexed with 8-mer influenza pb1 peptide

Structure:

Mhc class i antigen. Chain: a, d. Engineered: yes. Beta-2-microglobulin. Chain: b, e. Synonym: hb2m. Engineered: yes. Pb1 peptide. Chain: c, f.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosseta2. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes.

Resolution:

1.89Å R-factor: 0.201 R-free: 0.232

Authors:

M.Asa,D.Morita,M.Sugita

Key ref:

M.Asa et al. Crystal structures of n-Myristoylated lipopeptide-Bou class i complexes indicate reorganization of b-Pocket architecture upon ligand binding.. J biol chem, . PubMed id: 35667438

Date:

03-Feb-22 Release date: 22-Jun-22

Protein chain

A0A5H2UYS3  (A0A5H2UYS3_HUMAN) -  MHC class I antigen from Homo sapiens

Seq: 367 a.a.

Struc: 277 a.a.

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.

Protein chain

A0A5H2UYS3  (A0A5H2UYS3_HUMAN) -  MHC class I antigen from Homo sapiens

Seq: 367 a.a.

Struc: 233 a.a.*

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 89 a.a.

* PDB and UniProt seqs differ at 5 residue positions (black crosses)