PDBsum entry 7wjs

Protein binding

PDB id: 7wjs

Contents

Protein chains

108 a.a.

Ligands

JFL ×3

GOL ×9

Waters ×18

PDB id:

7wjs

Name:

Protein binding

Title:

Crystal structure of the first bromodomain of human brd4 in complex with the inhibitor y13157

Structure:

Bromodomain-containing protein 4. Chain: a, b, c. Synonym: protein hunk1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Resolution:

2.73Å R-factor: 0.183 R-free: 0.215

Authors:

J.Li,C.Zhang,H.Xu,X.Zhuang,X.Wu,Y.Zhang,Y.Xu

Key ref:

J.Li et al. (2022). Structure-Based discovery and optimization of furo[3, ]Pyridin-4(5 h )-One derivatives as potent and second bromodomain (bd2)-Selective bromo and extra terminal (bet) inhibitors.. J med chem, 65, 5760. PubMed id: 35333526

Date:

07-Jan-22 Release date: 10-Aug-22

Protein chains

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 108 a.a.