PDBsum entry 7vqx

Structural protein

PDB id: 7vqx

Contents

Protein chains

237 a.a.

340 a.a.

55 a.a.

27 a.a.

128 a.a.

361 a.a.

PDB id:

7vqx

Name:

Structural protein

Title:

Cryo-em structure of human vasoactive intestinal polypeptide receptor 2 (vip2r) in complex with pacap27 and gs

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Bos taurus. Cattle. Organism_taxid: 9913. Gene: gnas, gnas1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

Y.N.Xu,W.B.Feng,Q.T.Zhou,A.Y.Liang,J.Li,A.T.Dai,F.H.Zhao,J.H.Yan, C.W.Chen,H.Li,L.H.Zhao,T.Xia,Y.Jiang,H.E.Xu,D.H.Yang,M.W.Wang

Key ref:

Y.Xu et al. (2022). A distinctive ligand recognition mechanism by the hum vasoactive intestinal polypeptide receptor 2.. Nat commun, 13, 2272. PubMed id: 35477937

Date:

21-Oct-21 Release date: 18-May-22

Protein chain

P04896  (GNAS2_BOVIN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Bos taurus

Seq: 394 a.a.

Struc: 237 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 340 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

P18509  (PACA_HUMAN) -  Pituitary adenylate cyclase-activating polypeptide from Homo sapiens

Seq: 176 a.a.

Struc: 27 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P41587  (VIPR2_HUMAN) -  Vasoactive intestinal polypeptide receptor 2 from Homo sapiens

Seq: 438 a.a.

Struc: 361 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????