 |
PDBsum entry 7v0e
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Crystal structure of the macro-oligomeric form of dnmt3b methyltransferase domain.
|
|
Structure:
|
|
DNA (cytosine-5)-methyltransferase 3b. Chain: a, b, c, d, e, f, g, h. Synonym: dnmt3b,DNA methyltransferase hsaiiib,DNA mtase hsaiiib, m.Hsaiiib. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: dnmt3b. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Resolution:
|
|
|
3.27Å
|
R-factor:
|
0.206
|
R-free:
|
0.235
|
|
|
Authors:
|
|
L.Gao,J.Lu,J.Song
|
|
Key ref:
|
|
L.Gao
Structure of dnmt3b homotetramer reveals basis of fun impairment by icf disease.
To be published,
.
PubMed id:
|
|
|
Date:
|
|
|
10-May-22
|
Release date:
|
22-Jun-22
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q9UBC3
(DNM3B_HUMAN) -
DNA (cytosine-5)-methyltransferase 3B from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
853 a.a.
271 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.1.1.37
- Dna (cytosine-5-)-methyltransferase.
|
|
|
|
|
|
|
Reaction:
|
|
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl- 2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H+
|
|
|
|
|
|
2'-deoxycytidine in DNA
|
+
|
S-adenosyl-L-methionine
|
=
|
5-methyl- 2'-deoxycytidine in DNA
|
+
|
S-adenosyl-L-homocysteine
|
+
|
H(+)
Bound ligand (Het Group name = )
corresponds exactly
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
