PDBsum entry 7upy

Viral protein

PDB id: 7upy

Contents

Protein chains

1109 a.a.

225 a.a.

212 a.a.

Ligands

NAG-NAG ×16

NAG-NAG-MAN ×12

NAG-NAG-FUC ×6

NAG ×23

PDB id:

7upy

Name:

Viral protein

Title:

An antibody from single human vh-rearranging mouse neutralizes all sars-cov-2 variants through ba.5 by inhibiting membrane fusion

Structure:

Spike glycoprotein. Chain: a, b, c. Synonym: s glycoprotein,e2,peplomer protein. Engineered: yes. Mutation: yes. Sp1-77 fab heavy chain. Chain: h, d, f. Engineered: yes. Sp1-77 fab light chain.

Source:

Severe acute respiratory syndrome coronavirus. Organism_taxid: 2901879. Gene: s, 2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens, mus musculus. Human, mouse. Organism_taxid: 9606, 10090. Expression_system_taxid: 9606

Authors:

J.Zhang,S.Luo,A.Kreutzberger,T.Kirchhausen,B.Chen,B.Haynes,F.Alt

Key ref:

S.Luo et al. Humanized antibody potently neutralizes all sars-Cov- Variants by a novel mechanism. To be published, . PubMed id: 35951767

Date:

18-Apr-22 Release date: 10-Aug-22

Protein chains

P0DTC2  (SPIKE_SARS2) -  Spike glycoprotein from Severe acute respiratory syndrome coronavirus 2

Seq: 1273 a.a.

Struc: 1109 a.a.*

Protein chains

No UniProt id for this chain

Struc: 225 a.a.

Protein chains

No UniProt id for this chain

Struc: 212 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)