PDBsum entry 7ujy

Transcription

PDB id

7ujy

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Contents

			Protein chains

					231 a.a.


					228 a.a.

			Ligands

					RL4 ×4

			Waters ×633

PDB id:

7ujy

Links

Name:

Transcription

Title:

Estrogen receptor alpha ligand binding domain y537s mutant in complex with a methylated lasofoxifene derivative that enhances estrogen receptor alpha nuclear resonance time

Structure:

Estrogen receptor. Chain: b, a, c, d. Synonym: er,er-alpha,estradiol receptor,nuclear receptor subfamily 3 group a member 1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: esr1, esr, nr3a1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.70Å

R-factor:

0.190

R-free:

0.224

Authors:

D.J.Hosfield,G.L.Greene,S.W.Fanning

Key ref:

D.J.Hosfield et al. (2022). Stereospecific lasofoxifene derivatives reveal the in between estrogen receptor alpha stability and antagon activity in esr1 mutant breast cancer cells.. Elife, 11, . PubMed id: 35575456

Date:

31-Mar-22

Release date:

15-Jun-22

Supersedes:

6vpk

PROCHECK