PDBsum entry 7ujs

Transferase

PDB id: 7ujs

Contents

Protein chains

268 a.a.

16 a.a.

Ligands

ADP

PDB id:

7ujs

Name:

Transferase

Title:

Cocrystal structure of human camkii-alpha (camk2a)kinase domain and glun2b in complex with adp

Structure:

Calcium/calmodulin-dependent protein kinase type ii subunit alpha. Chain: a. Synonym: camk-ii subunit alpha. Engineered: yes. Mutation: yes. Glutamate receptor ionotropic, nmda 2b. Chain: b. Synonym: glun2b,glutamate [nmda] receptor subunit epsilon-2,n-methyl

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: camk2a, camka, kiaa0968. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.75Å R-factor: 0.201 R-free: 0.262

Authors:

C.Ozden,N.J.Santos,M.M.Stratton,S.C.Garman

Key ref:

C.Ozden et al. Cocrystal structure of human camkii-Alpha (camk2a)kin domain and glun2b in complex with ADP. To be published, . PubMed id: 35830796

Date:

31-Mar-22 Release date: 13-Apr-22

Supersedes:

6xdu

Protein chain

Q9UQM7  (KCC2A_HUMAN) -  Calcium/calmodulin-dependent protein kinase type II subunit alpha from Homo sapiens

Seq: 478 a.a.

Struc: 268 a.a.*

Protein chain

Q13224  (NMDE2_HUMAN) -  Glutamate receptor ionotropic, NMDA 2B from Homo sapiens

Seq: 1484 a.a.

Struc: 16 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.11.17 - calcium/calmodulin-dependent protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] (Bound ligand (Het Group name = ADP) corresponds exactly) + ADP + H(+)

L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] (Bound ligand (Het Group name = ADP) corresponds exactly) + ADP + H(+)

• Cofactor: Ca(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site