PDBsum entry 7tyk

Signaling protein

PDB id: 7tyk

Contents

Protein chains

809 a.a.

PDB id:

7tyk

Name:

Signaling protein

Title:

Cryo-em structure of insulin receptor-related receptor (irr) in apo- state captured at ph 7. The 3d refinement was applied with c2 symmetry

Structure:

Insulin receptor-related protein. Chain: a, b. Synonym: irr,ir-related receptor. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: insrr, irr. Expressed in: homo sapiens. Expression_system_taxid: 9606

Authors:

L.W.Wang,C.Hall,J.Li,E.Choi,X.C.Bai

Key ref:

L.W.Wang et al. Structural basis of the alkaline ph-Dependent activat insulin receptor-Related receptor. To be published, . PubMed id: 37055497

Date:

13-Feb-22 Release date: 15-Feb-23

Protein chains

P14616  (INSRR_HUMAN) -  Insulin receptor-related protein from Homo sapiens

Seq: 1297 a.a.

Struc: 809 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site