PDBsum entry 7tx4

Viral protein

PDB id: 7tx4

Contents

Protein chain

167 a.a.

Waters ×194

PDB id:

7tx4

Name:

Viral protein

Title:

Neutron crystal structure of sars-cov-2 nsp3 macrodomain at 293 k (p21 crystal form)

Structure:

Papain-like protease nsp3. Chain: a. Fragment: macrodomain. Synonym: non-structural protein 3,nsp3,pl2-pro,papain-like proteinase,pl-pro. Engineered: yes

Source:

Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049. Gene: rep, 1a-1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.90Å R-factor: 0.166 R-free: 0.224

Authors:

G.J.Correy,J.S.Fraser,A.Kovalevsky

Key ref:

G.J.Correy and j.s.fraser Neutron crystal structure of sars-Cov-2 nsp3 macrodom 293 k (p21 crystal form). To be published, . PubMed id: 35622909

Date:

07-Feb-22 Release date: 23-Feb-22

Protein chain

P0DTD1  (R1AB_SARS2) -

Enzyme reactions

• Enzyme class: E.C.3.4.19.12,3.4.22.- - ubiquitinyl hydrolase 1.
• Reaction: Thiol-dependent hydrolysis of ester, thiolester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).