PDBsum entry 7tnh

Transferase

PDB id: 7tnh

Contents

Protein chain

280 a.a.

Ligands

I9W

Metals

_NA

_CL ×4

Waters ×9

PDB id:

7tnh

Name:

Transferase

Title:

Crystal structure of csf1r kinase domain in complex with dp-6233

Structure:

Macrophage colony-stimulating factor 1 receptor,fibroblast growth factor receptor 1 chimera. Chain: a. Synonym: csf-1 receptor,csf-1-r,csf-1r,m-csf-r,proto-oncogenE C-fms, fgfr-1,basic fibroblast growth factor receptor 1,bfgfr,bfgf-r-1,fms- like tyrosine kinase 2,flt-2,n-sam,proto-oncogenE C-fgr. Engineered: yes. Other_details: csf1r residues 549-922 with the native kid substituted with the kid of fgfr

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms, fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Resolution:

2.70Å R-factor: 0.217 R-free: 0.269

Authors:

T.E.Edwards,T.L.Arakaki,L.Chun,D.L.Flynn

Key ref:

T.M.Caldwell et al. Discovery of acyl ureas as highly selective small mol csf1r kinase inhibitors.. Bioorg med chem lett, . PubMed id: 35961461

Date:

21-Jan-22 Release date: 24-Aug-22

Protein chain

P07333  (CSF1R_HUMAN) -  Macrophage colony-stimulating factor 1 receptor from Homo sapiens

Seq: 972 a.a.

Struc: 280 a.a.*

Protein chain

P11362  (FGFR1_HUMAN) -  Fibroblast growth factor receptor 1 from Homo sapiens

Seq: 822 a.a.

Struc: 280 a.a.*

* PDB and UniProt seqs differ at 132 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site