PDBsum entry 7th3

Immune system/toxin

PDB id: 7th3

Contents

Protein chains

257 a.a.

117 a.a.

Waters ×239

PDB id:

7th3

Name:

Immune system/toxin

Title:

Single-domain vhh intrabodies neutralize ricin toxin

Structure:

Ricin chain a. Chain: a. Engineered: yes. Vhh antibody. Chain: b. Engineered: yes

Source:

Ricinus communis. Castor bean. Organism_taxid: 3988. Expressed in: escherichia coli. Expression_system_taxid: 866768. Vicugna pacos. Organism_taxid: 30538.

Resolution:

2.29Å R-factor: 0.249 R-free: 0.272

Authors:

M.J.Rudolph

Key ref:

T.F.Czajka et al. (2022). Single-Domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal p-Sta proteins.. J biol chem, 298, 01742. PubMed id: 35182523

Date:

10-Jan-22 Release date: 12-Oct-22

Protein chain

P02879  (RICI_RICCO) -  Ricin from Ricinus communis

Seq: 576 a.a.

Struc: 257 a.a.

Protein chain

No UniProt id for this chain

Struc: 117 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.2.2.22 - rRNA N-glycosylase.
• Reaction: Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.