PDBsum entry 7t8h

Oxidoreductase

PDB id

7t8h

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Contents

			Protein chains

					153 a.a.

			Ligands

					ACT


					Q8E ×2


					SO4 ×2

			Metals

					_ZN ×4

			Waters ×223

PDB id:

7t8h

Links

Name:

Oxidoreductase

Title:

G93a mutant of human sod1 bound with mr6-26-2 in p21 space group

Structure:

Superoxide dismutase [cu-zn]. Chain: a, f. Synonym: superoxide dismutase 1,hsod1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sod1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.50Å

R-factor:

0.186

R-free:

0.224

Authors:

K.Amporndanai,S.S.Hasnain

Key ref:

K.Amporndanai et al. Disease onset and its course are delayed by on-Target cellular sod1 engagement of organo-Selenium drug comp for amyotrophic lateral sclerosis. To be published, . PubMed id: 38802492

Date:

16-Dec-21

Release date:

25-Jan-23

PROCHECK

	Headers

	References

Protein chains

P00441 (SODC_HUMAN) - Superoxide dismutase [Cu-Zn] from Homo sapiens

Seq: Struc:					154 a.a. 153 a.a.*

Key:

Secondary structure

* PDB and UniProt seqs differ at 1 residue position (black cross)



		Enzyme reactions

Enzyme class:

E.C.1.15.1.1 - superoxide dismutase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

2 superoxide + 2 H⁺ = H2O2 + O2

2 × superoxide	+	2 × H(+)	=	H2O2	+	O2

Cofactor:

Fe cation or Mn(2+) or (Zn(2+) and Cu cation)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site