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PDBsum entry 7svn
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PDB id:
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Hydrolase
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Title:
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Dpp9 in complex with ligand iced-1
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Structure:
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Dipeptidyl peptidase 9. Chain: a, b, c, d. Synonym: dp9,dipeptidyl peptidase iv-related protein 2,dprp-2, dipeptidyl peptidase ix,dpp ix,dipeptidyl peptidase-like protein 9, dplp9. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp9, dprp2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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2.78Å
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R-factor:
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0.268
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R-free:
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0.349
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Authors:
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A.Lammens,K.Hollenstein,D.J.Klein
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Key ref:
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K.P.Moore
et al.
(2022).
A phenotypic screen identifies potent dpp9 inhibitors capable of killing HIV-1 infected cells..
Acs chem biol,
17,
2595.
PubMed id:
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Date:
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19-Nov-21
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Release date:
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05-Oct-22
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PROCHECK
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Headers
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References
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Q86TI2
(DPP9_HUMAN) -
Dipeptidyl peptidase 9 from Homo sapiens
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Seq:
Struc:
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863 a.a.
825 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.3.4.14.5
- dipeptidyl-peptidase Iv.
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Reaction:
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Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc, from a polypeptide, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
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Links
