PDBsum entry 7ssm

Immune system

PDB id: 7ssm

Contents

Protein chain

169 a.a.

Ligands

B7L

Waters ×38

PDB id:

7ssm

Name:

Immune system

Title:

Crystal structure of human sting r232 in complex with compound 11

Structure:

Stimulator of interferon genes protein. Chain: a. Synonym: transmembrane protein 173. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sting, loc340061, hcg_1782396. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.96Å R-factor: 0.209 R-free: 0.250

Authors:

J.S.Sack,D.A.Critton

Key ref:

e.c.cherney et al. (2022). Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization. J.Med.Chem., 0, . PubMed id: 35108011

Date:

11-Nov-21 Release date: 09-Feb-22

Protein chain

Q86WV6  (STING_HUMAN) -  Stimulator of interferon genes protein from Homo sapiens

Seq: 379 a.a.

Struc: 169 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

J.Med.Chem. 0: (2022)

PubMed id: 35108011

Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.

e.c.cherney, l.zhang, j.lo, t.huynh, d.wei, v.ahuja, c.quesg.schieven, a.futran, g.locke, z.lin, l.monereau, c.chaudhj.blum, s.li, m.fereshtah, b.li-wang, s.gangwar, c.pan, c.cs.zhu, s.posy, j.s.sack, p.zhang, m.ruzanov, m.harner, f.akg.schroeder, g.vite, b.fink.

ABSTRACT

No abstract given.