PDBsum entry 7srs

Membrane protein

PDB id: 7srs

Contents

Protein chains

107 a.a.

127 a.a.

289 a.a.

355 a.a.

119 a.a.

106 a.a.

Ligands

NAG

7LD

PDB id:

7srs

Name:

Membrane protein

Title:

5-ht2b receptor bound to lsd in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoem)

Structure:

Anti-5ht2br fab light chain. Chain: p. Engineered: yes. Anti-5ht2br fab heavy chain. Chain: q. Engineered: yes. 5-hydroxytryptamine receptor 2b. Chain: r. Engineered: yes.

Source:

Mus musculus. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606. Gene: htr2b. Gene: arrb1, arr1.

Authors:

X.Barros-Alvarez,C.Cao,O.Panova,B.L.Roth,G.Skiniotis

Key ref:

C.Cao et al. Signaling snapshots of a serotonin receptor activated prototypical psychedelic lsd.. Neuron, . PubMed id: 36087581

Date:

08-Nov-21 Release date: 21-Sep-22

Protein chain

No UniProt id for this chain

Struc: 107 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

P41595  (5HT2B_HUMAN) -  5-hydroxytryptamine receptor 2B from Homo sapiens

Seq: 481 a.a.

Struc: 289 a.a.*

Protein chain

P49407  (ARRB1_HUMAN) -  Beta-arrestin-1 from Homo sapiens

Seq: 418 a.a.

Struc: 355 a.a.*

Protein chain

No UniProt id for this chain

Struc: 119 a.a.

Protein chain

No UniProt id for this chain

Struc: 106 a.a.

* PDB and UniProt seqs differ at 13 residue positions (black crosses)