PDBsum entry 7rx9

Signaling protein

PDB id: 7rx9

Contents

Protein chain

432 a.a.

Ligands

SO4 ×6

PDB id:

7rx9

Name:

Signaling protein

Title:

Structure of autoinhibited p-rex1

Structure:

Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein, endolysin chimera. Chain: a. Synonym: p-rex1,ptdins(3,4,5)-dependent rac exchanger 1,lysis protein,lysozyme,muramidase,p-rex1,ptdins(3,4,5)-dependent rac exchanger 1. Engineered: yes

Source:

Homo sapiens, enterobacteria phage t4. Human, bacteriophage t4. Organism_taxid: 9606, 10665. Gene: prex1, kiaa1415. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

3.22Å R-factor: 0.238 R-free: 0.262

Authors:

A.M.Ellisdon,Y.Chang

Key ref:

Y.G.Chang et al. Structure of the metastatic factor p-Rex1 reveals a two-Layered autoinhibitory mechanism.. Nat struct mol biol, . PubMed id: 35864164

Date:

22-Aug-21 Release date: 10-Aug-22

Protein chain

P00720  (ENLYS_BPT4) -  Endolysin from Enterobacteria phage T4

Seq: 164 a.a.

Struc: 432 a.a.*

Protein chain

Q8TCU6  (PREX1_HUMAN) -  Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein from Homo sapiens

Seq: 1659 a.a.

Struc: 432 a.a.

* PDB and UniProt seqs differ at 144 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.2.1.17 - lysozyme.
• Reaction: Hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls.