PDBsum entry 7rtc

Hydrolase

PDB id: 7rtc

Contents

Protein chains

331 a.a.

Ligands

NCN ×3

PDB id:

7rtc

Name:

Hydrolase

Title:

Crystal structure of the arm domain from drosophila sarm1 in complex with namn

Structure:

NAD(+) hydrolase sarm1. Chain: a, b, c. Synonym: nadase sarm1,sterile alpha and tir motif-containing protein 1,tir-1 homolog. Engineered: yes

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: sarm, ect4, cg43119. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

3.31Å R-factor: 0.239 R-free: 0.257

Authors:

W.Gu,T.Ve,B.Kobe

Key ref:

Y.Sasaki et al. (2021). Nicotinic acid mononucleotide is an allosteric sarm1 inhibitor promoting axonal protection.. Exp neurol, 345, 13842. PubMed id: 34403688

Date:

13-Aug-21 Release date: 01-Sep-21

Protein chains

Q6IDD9  (SARM1_DROME) -  NAD(+) hydrolase sarm1 from Drosophila melanogaster

Seq: 1360 a.a.

Struc: 331 a.a.

Enzyme reactions

• Enzyme class: E.C.3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
• Reaction: NAD⁺ + H2O = ADP-D-ribose + nicotinamide + H⁺

NAD(+) + H2O (Bound ligand (Het Group name = NCN) matches with 46.67% similarity) = ADP-D-ribose + nicotinamide + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site