PDBsum entry 7rdh

Viral protein/de novo protein

PDB id: 7rdh

Contents

Protein chains

316 a.a.

172 a.a.

185 a.a.

57 a.a.

Ligands

NAG-NAG ×5

NAG-NAG-BMA ×2

NAG ×5

Waters ×94

PDB id:

7rdh

Name:

Viral protein/de novo protein

Title:

Crystal structure of the de novo designed binding protein h3mb in complex with the 1968 influenza a virus hemagglutinin

Structure:

Hemagglutinin ha1 chain. Chain: a, c, e. Engineered: yes. Hemagglutinin ha2 chain. Chain: b, d, f. Engineered: yes. Mutation: yes. De novo designed protein h3mb. Chain: g, h.

Source:

Influenza a virus (strain a/hong kong/1/1968 h3n2). Organism_taxid: 506350. Strain: a/hong kong/1/1968 h3n2. Gene: ha. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Escherichia coli. Organism_taxid: 562.

Resolution:

2.75Å R-factor: 0.235 R-free: 0.289

Authors:

R.U.Kadam,I.A.Wilson

Key ref:

l.cao et al. (2022). Design of protein-binding proteins from the target structure alone. Nature, 0, . PubMed id: 35332283

Date:

09-Jul-21 Release date: 04-May-22

Protein chains

Q91MA7  (HEMA_I68A4) -  Hemagglutinin from Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Seq: 566 a.a.

Struc: 316 a.a.*

Protein chains

Q91MA7  (HEMA_I68A4) -  Hemagglutinin from Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Seq: 566 a.a.

Struc: 172 a.a.*

Protein chain

Q91MA7  (HEMA_I68A4) -  Hemagglutinin from Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Seq: 566 a.a.

Struc: 185 a.a.*

Protein chains

No UniProt id for this chain

Struc: 57 a.a.

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Nature 0: (2022)

PubMed id: 35332283

Design of protein-binding proteins from the target structure alone.

l.cao, b.coventry, i.goreshnik, b.huang, j.s.park, k.m.judi.markovic, r.u.kadam, k.h.g.verschueren, k.verstraete, s.t.r.walsh, n.bennett, a.phal, a.yang, l.kozodoy, m.dewitl.picton, l.miller, e.m.strauch, n.d.debouver, a.pires, a.s.halabiya, b.hammerson, w.yang, s.bernard, l.stewart, i.a.wilson, h.ruohola-baker, j.schlessinger, s.lee, s.n.savvides, k.c.garcia, d.baker.

ABSTRACT

No abstract given.