PDBsum entry 7r4x

Ribosome

PDB id: 7r4x

Contents

Protein chains

20 a.a.

210 a.a.

224 a.a.

257 a.a.

182 a.a.

184 a.a.

205 a.a.

97 a.a.

141 a.a.

123 a.a.

139 a.a.

131 a.a.

143 a.a.

143 a.a.

104 a.a.

83 a.a.

140 a.a.

99 a.a.

59 a.a.

55 a.a.

219 a.a.

227 a.a.

185 a.a.

104 a.a.

150 a.a.

127 a.a.

129 a.a.

122 a.a.

72 a.a.

82 a.a.

55 a.a.

64 a.a.

312 a.a.

206 a.a.

DNA/RNA

Metals

_MG ×88

__K ×82

_ZN ×3

Waters ×4117

PDB id:

7r4x

Name:

Ribosome

Title:

Cryo-em reconstruction of the human 40s ribosomal subunit - full map

Structure:

60s ribosomal protein l41. Chain: n. Synonym: hg12,large ribosomal subunit protein el41. 18s ribosomal RNA. Chain: 2. 40s ribosomal protein s3a. Chain: b. Synonym: small ribosomal subunit protein es1,v-fos transformation effector protein,fte-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Authors:

S.Pellegrino,K.C.Dent,T.Spikes,A.J.Warren

Key ref:

S.Pellegrino et al. Cryo-Em reconstruction of the human 40s ribosomal sub 2.15 angstrom resolution.. Nucleic acids res, . PubMed id: 36951107

Date:

09-Feb-22 Release date: 22-Feb-23

Protein chain

P62945  (RL41_HUMAN) -  Small ribosomal subunit protein eS32 from Homo sapiens

Seq: 25 a.a.

Struc: 20 a.a.

Protein chain

P61247  (RS3A_HUMAN) -  Small ribosomal subunit protein eS1 from Homo sapiens

Seq: 264 a.a.

Struc: 210 a.a.

Protein chain

P23396  (RS3_HUMAN) -  Small ribosomal subunit protein uS3 from Homo sapiens

Seq: 243 a.a.

Struc: 224 a.a.

Protein chain

P62701  (RS4X_HUMAN) -  Small ribosomal subunit protein eS4, X isoform from Homo sapiens

Seq: 263 a.a.

Struc: 257 a.a.

Protein chain

P46782  (RS5_HUMAN) -  Small ribosomal subunit protein uS7 from Homo sapiens

Seq: 204 a.a.

Struc: 182 a.a.

Protein chain

P62081  (RS7_HUMAN) -  Small ribosomal subunit protein eS7 from Homo sapiens

Seq: 194 a.a.

Struc: 184 a.a.

Protein chain

P62241  (RS8_HUMAN) -  Small ribosomal subunit protein eS8 from Homo sapiens

Seq: 208 a.a.

Struc: 205 a.a.

Protein chain

P46783  (RS10_HUMAN) -  Small ribosomal subunit protein eS10 from Homo sapiens

Seq: 165 a.a.

Struc: 97 a.a.

Protein chain

P62280  (RS11_HUMAN) -  Small ribosomal subunit protein uS17 from Homo sapiens

Seq: 158 a.a.

Struc: 141 a.a.

Protein chain

P62841  (RS15_HUMAN) -  Small ribosomal subunit protein uS19 from Homo sapiens

Seq: 145 a.a.

Struc: 123 a.a.

Protein chain

P62249  (RS16_HUMAN) -  Small ribosomal subunit protein uS9 from Homo sapiens

Seq: 146 a.a.

Struc: 139 a.a.

Protein chain

P08708  (RS17_HUMAN) -  Small ribosomal subunit protein eS17 from Homo sapiens

Seq: 135 a.a.

Struc: 131 a.a.

Protein chain

P62269  (RS18_HUMAN) -  Small ribosomal subunit protein uS13 from Homo sapiens

Seq: 152 a.a.

Struc: 143 a.a.

Protein chain

P39019  (RS19_HUMAN) -  Small ribosomal subunit protein eS19 from Homo sapiens

Seq: 145 a.a.

Struc: 143 a.a.

Protein chain

P60866  (RS20_HUMAN) -  Small ribosomal subunit protein uS10 from Homo sapiens

Seq: 119 a.a.

Struc: 104 a.a.

Protein chain

P63220  (RS21_HUMAN) -  Small ribosomal subunit protein eS21 from Homo sapiens

Seq: 83 a.a.

Struc: 83 a.a.*

Protein chain

P62266  (RS23_HUMAN) -  Small ribosomal subunit protein uS12 from Homo sapiens

Seq: 143 a.a.

Struc: 140 a.a.*

Protein chain

P62854  (RS26_HUMAN) -  Small ribosomal subunit protein eS26 from Homo sapiens

Seq: 115 a.a.

Struc: 99 a.a.

Protein chain

P62857  (RS28_HUMAN) -  Small ribosomal subunit protein eS28 from Homo sapiens

Seq: 69 a.a.

Struc: 59 a.a.

Protein chain

P62273  (RS29_HUMAN) -  Small ribosomal subunit protein uS14 from Homo sapiens

Seq: 56 a.a.

Struc: 55 a.a.

Protein chain

P15880  (RS2_HUMAN) -  Small ribosomal subunit protein uS5 from Homo sapiens

Seq: 293 a.a.

Struc: 219 a.a.

Protein chain

P62753  (RS6_HUMAN) -  Small ribosomal subunit protein eS6 from Homo sapiens

Seq: 249 a.a.

Struc: 227 a.a.

Protein chain

P46781  (RS9_HUMAN) -  Small ribosomal subunit protein uS4 from Homo sapiens

Seq: 194 a.a.

Struc: 185 a.a.

Protein chain

P25398  (RS12_HUMAN) -  Small ribosomal subunit protein eS12 from Homo sapiens

Seq: 132 a.a.

Struc: 104 a.a.

Protein chain

P62277  (RS13_HUMAN) -  Small ribosomal subunit protein uS15 from Homo sapiens

Seq: 151 a.a.

Struc: 150 a.a.

Protein chain

P62263  (RS14_HUMAN) -  Small ribosomal subunit protein uS11 from Homo sapiens

Seq: 151 a.a.

Struc: 127 a.a.*

Protein chain

P62244  (RS15A_HUMAN) -  Small ribosomal subunit protein uS8 from Homo sapiens

Seq: 130 a.a.

Struc: 129 a.a.

Protein chain

P62847  (RS24_HUMAN) -  Small ribosomal subunit protein eS24 from Homo sapiens

Seq: 133 a.a.

Struc: 122 a.a.

Protein chain

P62851  (RS25_HUMAN) -  Small ribosomal subunit protein eS25 from Homo sapiens

Seq: 125 a.a.

Struc: 72 a.a.

Protein chain

P42677  (RS27_HUMAN) -  Small ribosomal subunit protein eS27 from Homo sapiens

Seq: 84 a.a.

Struc: 82 a.a.

Protein chain

P62861  (RS30_HUMAN) -  Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein from Homo sapiens

Seq: 133 a.a.

Struc: 55 a.a.

Protein chain

P62979  (RS27A_HUMAN) -  Ubiquitin-ribosomal protein eS31 fusion protein from Homo sapiens

Seq: 156 a.a.

Struc: 64 a.a.

Protein chain

P63244  (RACK1_HUMAN) -  Small ribosomal subunit protein RACK1 from Homo sapiens

Seq: 317 a.a.

Struc: 312 a.a.

Protein chain

P08865  (RSSA_HUMAN) -  Small ribosomal subunit protein uS2 from Homo sapiens

Seq: 295 a.a.

Struc: 206 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

DNA/RNA chain

U-A-C-C-U-G-G-U-U-G-A-U-C-C-U-G-C-C-A-G-U-A-G-C-A-U-A2M-U-G-C-U-U-G-U-C-PSU-C- ... 1646 bases

Enzyme reactions

• Enzyme class: Chain D: E.C.4.2.99.18 - DNA-(apurinic or apyrimidinic site) lyase.
• Reaction: 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)- 2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho- 2'-deoxyribonucleoside-DNA + H⁺