PDBsum entry 7r3v

Electron transport

PDB id: 7r3v

Contents

Protein chains

445 a.a.

413 a.a.

379 a.a.

239 a.a.

196 a.a.

99 a.a.

74 a.a.

65 a.a.

46 a.a.

59 a.a.

Ligands

PG4 ×3

6PE

CDL ×3

HEM ×2

LMT

PEE ×2

I2Q

DMS

PO4 ×9

HEC

FES

PX4

Waters ×45

PDB id:

7r3v

Name:

Electron transport

Title:

Crystal structure of bovine cytochrome bc1 in complex with inhibitor ck-2-67.

Structure:

Cytochrome b-c1 complex subunit 1, mitochondrial. Chain: a. Synonym: complex iii subunit 1,core protein i,ubiquinol-cytochromE-C reductase complex core protein 1. Cytochrome b-c1 complex subunit 2, mitochondrial. Chain: b. Synonym: complex iii subunit 2,core protein ii,ubiquinol-cytochromE-C reductase complex core protein 2. Cytochrome b.

Source:

Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913

Resolution:

3.20Å R-factor: 0.208 R-free: 0.256

Authors:

N.Pinthong,K.Amporndanai,P.M.O'Neill,S.S.Hasnain,S.Antonyuk

Key ref:

K.Amporndanai et al. (2022). Targeting the ubiquinol-Reduction (q i ) site of the mitochondrial cytochrome bc 1 complex for the develop next generation quinolone antimalarials.. Biology (basel), 11, . PubMed id: 35892964

Date:

07-Feb-22 Release date: 10-Aug-22

Protein chain

P31800  (QCR1_BOVIN) -  Cytochrome b-c1 complex subunit 1, mitochondrial from Bos taurus

Seq: 480 a.a.

Struc: 445 a.a.*

Protein chain

P23004  (QCR2_BOVIN) -  Cytochrome b-c1 complex subunit 2, mitochondrial from Bos taurus

Seq: 453 a.a.

Struc: 413 a.a.

Protein chain

P00157  (CYB_BOVIN) -  Cytochrome b from Bos taurus

Seq: 379 a.a.

Struc: 379 a.a.

Protein chain

P00125  (CY1_BOVIN) -  Cytochrome c1, heme protein, mitochondrial from Bos taurus

Seq: 325 a.a.

Struc: 239 a.a.

Protein chain

P13272  (UCRI_BOVIN) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial from Bos taurus

Seq: 274 a.a.

Struc: 196 a.a.

Protein chain

P00129  (QCR7_BOVIN) -  Cytochrome b-c1 complex subunit 7 from Bos taurus

Seq: 111 a.a.

Struc: 99 a.a.*

Protein chain

P13271  (QCR8_BOVIN) -  Cytochrome b-c1 complex subunit 8 from Bos taurus

Seq: 82 a.a.

Struc: 74 a.a.

Protein chain

P00126  (QCR6_BOVIN) -  Cytochrome b-c1 complex subunit 6, mitochondrial from Bos taurus

Seq: 91 a.a.

Struc: 65 a.a.

Protein chain

P13272  (UCRI_BOVIN) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial from Bos taurus

Seq: 274 a.a.

Struc: 46 a.a.

Protein chain

P00130  (QCR9_BOVIN) -  Cytochrome b-c1 complex subunit 9 from Bos taurus

Seq: 64 a.a.

Struc: 59 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class 2: Chains A, B, C, F, G, H, J: E.C.?
• Enzyme class 3: Chains D, E, I: E.C.7.1.1.8 - quinol--cytochrome-c reductase.
• Reaction: a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)- [cytochrome c](out) + 2 H(+)(out)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site