PDBsum entry 7qpm

Hydrolase

PDB id: 7qpm

Contents

Protein chains

315 a.a.

Ligands

EEI ×2

Metals

_MG ×2

_ZN ×2

Waters ×234

PDB id:

7qpm

Name:

Hydrolase

Title:

Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate

Structure:

Camp and camp-inhibited cgmp 3',5'-cyclic phosphodiesterase 10a. Chain: a, b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.40Å R-factor: 0.178 R-free: 0.250

Authors:

P.M.Leonard,M.Langgard

Key ref:

J.Kehler et al. Discovery of lu af11167, A phosphodiesterase 10a inhi clinical candidate. To be published, .

Date:

05-Jan-22 Release date: 19-Apr-23

Protein chains

Q9Y233  (PDE10_HUMAN) -  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A from Homo sapiens

Seq: 1055 a.a.

Struc: 315 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.4.17 - 3',5'-cyclic-nucleotide phosphodiesterase.
• Reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site