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PDBsum entry 7qlp

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Hydrolase PDB id
7qlp

 

 

 

 

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Contents
Protein chains
(+ 0 more) 263 a.a.
Ligands
TBE ×4
ACT
TRS
EDO
Waters ×828
PDB id:
7qlp
Name: Hydrolase
Title: Structure of beta-lactamase tem-171 complexed with tazobactam intermediate at 2.3 a resolution
Structure: Beta-lactamase tem. Chain: a, b, c, d, e, f. Synonym: irt-4,penicillinase,tem-1,tem-16/caz-7,tem-2,tem-24/caz-6, tem-3,tem-4,tem-5,tem-6,tem-8/caz-2. Engineered: yes. Mutation: yes
Source: Escherichia coli. Organism_taxid: 562. Gene: bla, blat-3, blat-4, blat-5, blat-6. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.30Å     R-factor:   0.190     R-free:   0.217
Authors: J.Hakanpaa,T.Petrova,V.R.Samygina,V.S.Lamzin,A.M.Egorov
Key ref: V.G.Grigorenko et al. (2022). Crystal structures of the molecular class a beta-Lact tem-171 and its complexes with tazobactam.. Acta crystallogr d struct, 78, 825. PubMed id: 35775982
Date:
20-Dec-21     Release date:   13-Jul-22    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P62593  (BLAT_ECOLX) -  Beta-lactamase TEM from Escherichia coli
Seq:
Struc:
286 a.a.
263 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.5.2.6  - beta-lactamase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Penicillin Biosynthesis and Metabolism
      Reaction: a beta-lactam + H2O = a substituted beta-amino acid
      Cofactor: Zn(2+)

 

 

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